Supramolecularity creates nonstandard protein ligands.

Stabilizing Protein-Protein-Interactions with Multivalent Ligands

Huntington’s disorder (HD) is one of the neurodegenerative disorders in which the polyglutamine (polyQ) tract of the protein huntingtin (htt) is found to be expanded. First exon of this mutant htt protein is found in the inclusions in the brain of the patient suffering from HD, which is the pathological hallmark of the disease1. Exon-1 of htt comprises of 17 amino acid long N-terminal helix (Nt...

Where to Start? Alternate Protein Translation Mechanism Creates Unanticipated Antigens

Chemical reactions lie at the heart of many biological processes, from photosynthesis and respiration to cell signaling and drug metabolism. Thanks to an atmosphere rich in oxygen, many organisms use oxygen to carry out these life processes. But oxygen metabolism produces highly toxic by-products called reactive oxygen species. When oxidation outpaces detoxifying reactions, oxidative stress occ...

FOUNDATIONS OF NONSTANDARD ANALYSIS A Gentle Introduction to Nonstandard Extensions

Nonstandard Analysis in Topology: Nonstandard and Standard Compactifications

Let (X,T ) be a topological space, and X a non–standard extension of X . There is a natural “standard” topology T on X generated by G, where G ∈ T . The topological space ( X, T ) will be used to study, in a systematic way, compactifications of (X,T ) . Mathematics Subject Classification: 031105, 54J05, 54D35, 54D60.

Smoothing images creates corners

The isophote curvature times the gradient magnitude to some power has been studied in the literature as a measure of cornerness in images. Stability in terms of sampling noise has been proposed by selecting corners at high scale and locating them at fine scale. We will examine the problem of tracking extrema of these measures in the Linear Scale-Space using catastrophe theory. This enables us t...